miR‐191 modulates B‐cell development and targets transcription factors E2A, Foxp1, and Egr1
نویسندگان
چکیده
منابع مشابه
Transcription Factors E2A, FOXO1 and FOXP1 Regulate Recombination Activating Gene Expression in Cancer Cells
It has long been accepted that immunoglobulins (Igs) were produced by B lymphoid cells only. Recently Igs have been found to be expressed in various human cancer cells and promote tumor growth. Recombination activating gene 1 (RAG1) and RAG2, which are essential enzymes for initiating variable-diversity-joining segment recombination, have also been found to be expressed in cancer cells. However...
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15 صفحه اولMolecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development
E2A is an essential regulator of early B cell development. Here, we have demonstrated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development. As shown by the identification of regulated E2A,E2-2 target genes in activated B cells, these E-proteins directly activated genes with important functions in GC B cells and plasma cells by inducing and maintaining D...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2018
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201847660